FORMULATION AND EVALUATION OF LEVOFLOXACIN-CHITOSAN / β- CYCLODEXTRIN NANOPARTICLES BY IONIC GELATION
نویسندگان
چکیده
منابع مشابه
Formulation and evaluation of captropril microspheres by ionic gelation technique
The development of oral sustained or controlled release dosage form of captopril has been an interested topic of research for a long period of time. Difficulties encountered on the fact that the drug is freely water soluble. Such drug is difficult to be delivered orally in a sustained or controlled release manner and, Due to its effectiveness and intensive use as a drug of choice in the treatme...
متن کاملChitosan-based nanoparticles by ionotropic gelation
Ionotropic gelation between chitosan, as the polycation of acidic pH, and TPP (penta sodium triphosphate aka tripolyphosphate) as the anionic oligomeric partner leads to the formation of colloidal systems which can range from approximately 100nm to 2000nm. Depending on the conditions, particles with different properties can be obtained including differences in size, zeta potential, stability at...
متن کاملOptimization and development of insulin nanoparticles by new thiolated chitosan derivative with ionic gelation method using a model-based methodology
Insulin therapy has been the best choice for the clinical management of diabetes mellitus. The current insulin therapy is via subcutaneous injection, which often fails to mimic the glucose homeostasis that occurs in normal individuals. Oral delivery is the most convenient administration route. However, insulin cannot be well absorbed orally because of its rapid enzymatic degradation in the gast...
متن کاملFormulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres
Cholinergic neurotransmission loss is the main cause of cognitive impairment in patients with Alzheimer's disease. Phospholipids (PLs) play an essential role in memory and learning abilities. Moreover, PLs act as a source of choline in acetylcholine synthesis. This study aimed to prepare and optimize the formulation of chitosan/phospholipid/β-cyclodextrin (CTS/PL/β-CD) microspheres that can imp...
متن کاملInfluence of Formulation and Process Variables on the Formation of Rifampicin Nanoparticles by Ionic Gelation Technique
Chitosan, a natural biodegradable polymer is recommended for development of nanoparticles intended for chronic infection such as tuberculosis. Formulation and processing variables play a critical role in the formation of nanoparticles prepared with chitosan. The present study investigated the influence of polymer (chitosan) molecular weight, stabilizing agent (tween 80) concentration and stirri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2015
ISSN: 2250-1177
DOI: 10.22270/jddt.v5i2.1075